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Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula

Abstract
Chemical investigation of the marine cyanobacterium Lyngbya majuscula from Pulau Hantu Besar, Singapore, has led to the isolation of a cyclodepsipeptide, hantupeptin A (1). The planar structure of 1 was assigned on the basis of extensive 1D and 2D NMR spectroscopic experiments. The absolute configuration of the amino and hydroxyl acid residues in the molecule was determined by application of the advanced Marfey method, chiral HPLC analysis, and Mosher’s method. Hantupeptin A showed cytotoxicity to MOLT-4 leukemia cells and MCF-7 breast cancer cells with IC50 values of 32 and 4.0 µM, respectively.
Type
Journal Article
Type of thesis
Series
Citation
Tripathi, A., Puddick, J., Prinsep, M.R., Lee, P.P.F. & Tan, L.T. (2009). Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. Journal of Natural Products, 72(1), 29-32.
Date
2009
Publisher
American Chemical Society
Degree
Supervisors
Rights