Strohmaier, SarahMedvedev, Oleg N.2025-06-112025-06-112025Strohmaier, S., & Medvedev, O. N. (2025). A latent profile analysis of the Big Five personality and mindfulness traits in the general population. Personality and Individual Differences, 245. https://doi.org/10.1016/j.paid.2025.1132870191-8869https://hdl.handle.net/10289/17428Understanding how personality and mindfulness traits influence responses to health and wellbeing interventions is important for improving their effectiveness, in particular since there is likely not a one-size-fits-all approach for mindfulness. While various interventions show overall benefits, individual differences likely determine optimal intervention types and doses. A multinational sample of 636 general population adults (57.2 % female) completed self-report measures of personality and mindfulness traits, and state positive and negative affect scales before being randomly assigned to a single mindfulness practice of 5-min, 20-min, or an active control, after which state scales were completed again. The personality and mindfulness data were subjected to latent profile analysis, revealing three profiles, labelled 1) Mindful-adaptive, 2) Reserved-disengaged, and 3) Ruminative-preoccupied. Secondary analyses showed significant medium to large effects for profile 3 (Ruminative-preoccupied) across all groups. For profile 2 (Reserved-disengaged), shorter mindfulness practice had a significant medium to large effect. No significant interactions were found for profile 1 (Mindful-adaptive). Findings suggest that personality-mindfulness profiles predict differential responses to brief interventions. This has practical implications for personalizing health and wellbeing interventions based on individual personality characteristics. Our study provides a novel person-centered approach to understanding intervention effectiveness through personality profiling.enAttribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/Journal Article10.1016/j.paid.2025.11328752 Psychology5203 Clinical and Health Psychology5205 Social and Personality Psychology5201 Applied and Developmental Psychology5202 Biological psychology5205 Social and personality psychology3 Good Health and Well Being