Raju, SoniyaKularatna, NihalWilson, Marcus T.Steyn Ross, Alistair2025-02-122025-02-122024Raju, S., Kularatna, N., Wilson, M., & Steyn-Ross, D. A. (2024). Supercapacitor-based pulse generator with waveform adjustment capability for small animal transcranial magnetic stimulation. Biomedical Physics and Engineering Express, 11(1). https://doi.org/10.1088/2057-1976/ad9f6b2057-1976https://hdl.handle.net/10289/17177In transcranial magnetic stimulation (TMS), pulsed magnetic fields are applied to the brain, typically requiring high-power stimulators with high voltages and low series impedance. TMS pulse generators for small animal coils, are underexplored, with limited dedicated circuits and simulation models. Here, we present a new design for a high-power TMS pulse generator for small animals, utilizing a pre-charged supercapacitor that is sufficient to produce repeated pulses for TMS applications without the need for recharging. This approach eliminates the need for expensive high-voltage components and a high-voltage power supply. In this paper, we detail the design approach and basic block diagrams of a supercapacitor (SC) based TMS pulse generator, along with its experimental results. The findings indicate that the new circuit enables a complete test using just a single charge of an SC module. The proposed circuit functions as a versatile pulse-shaping device, where the MOSFET is treated as a dynamically varying resistor element rather than a traditional switch; allowing pulse parameter variations. We analyze a novel circuit for generating and controlling TMS pulses in small animal coils, and demonstrate its effectiveness through experimental results.enThis is an open access article distributed under the terms of the Creative Commons Attribution 4.0 license.http://creativecommons.org/licenses/by/4.0/Pulse circuitspulse shapingsupercapacitortranscranial magnetic stimulationJournal Article10.1088/2057-1976/ad9f6b2057-197640 Engineering4008 Electrical Engineering4009 Electronics, Sensors and Digital Hardware3206 Medical biotechnology4003 Biomedical engineering