Nicholson, Brian K.Henderson, WilliamDinger, Maarten B.2008-03-192007-11-142008-03-192003-11-01Nicholson, B. K., Henderson, W. & Dinger, M.B. (2003). Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand. Inorganica Chimica Acta, 355, 428-431.https://hdl.handle.net/10289/198Reaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt---Se---C---N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.enThis article is published in the journal Inorganica Chimica Acta, (c) 2003 Elsevier B.V.Platinum complexesSelenourea dianionThiourea dianionCrystal structuresAnticancer activityJournal Article10.1016/S0020-1693(03)00298-6