Agar, Nicholas2026-01-142026-01-142025Agar, N. (2025). How going to space changes the debate about radical human enhancement. Bioethics. https://doi.org/10.1111/bioe.700710269-9702https://hdl.handle.net/10289/17879This paper predicts that humans will venture into space and that, to survive and thrive in space, we will need to enhance our capacities radically. Moderate enhancement is insufficient for a humanity that commits to a future in Space. The paper is a partial retraction of the author's claims about the morality and prudential rationality of radical human enhancement. It allows that radical enhancement may be imprudent and immoral for Earth-bound humans, but essential for humans who settle in space. The paper advances a conjecture about how to assess which kinds of radical enhancements are required and which should be rejected. A humanity that commits to a future in Space may make progress on some disputes that today seem intractable.enThis is an accepted version of an article published in the journal Bioethics. © 2025 Wiley.Devonian periodhome in spacehuman enhancementradical enhancementspaceJournal Article10.1111/bioe.700711467-851950 Philosophy and Religious Studies5001 Applied Ethics5001 Applied ethics