Goss, Carol H. A.Henderson, WilliamWilkins, Alistair L.Evans, Cameron2009-11-242009-11-242003Goss, C. H. A., Henderson, W., Wilkins, A. L., & Evans, C. (2003). Synthesis, characterisation and biological activity of gold(III) catecholate and related complexes. Journal of Organometallic Chemistry, 679(2), 194-201.https://hdl.handle.net/10289/3408The reactions of the cyclometallated gold(III) complexes [LAuCl₂] [L=2-(dimethylaminomethyl)phenyl, 2-benzylpyridyl or 2-anilinopyridyl] with catechol, tetrachlorocatechol, or the cyclic α,β-diketone SCH(CO2Et)C(O)C(O)CH(CO2Et) give stable complexes containing five-membered Au-O-C-C-O rings. These represent the first examples of well-characterised gold(III) catecholate complexes. Similarly, reactions with 2-acetamidophenol [HOC₆H₄NHC(O)CH₃] give complexes with the related Au---N---C---C---O ring. The complexes were characterised by NMR spectroscopy, electrospray ionisation mass spectrometry, elemental microanalysis, and in the case of the complex [(2-benzylpyridyl)Au{OC₆H₄NC(O)CH₃}] by an X-ray crystal structure determination. Several complexes show high activity towards P388 murine leukemia cells.application/pdfenThis is an author’s accepted version of an article published in the Journal of Organometallic Chemistry. Copyright © 2003 Elsevier B.V. All rights reserved.goldcyclometallated complexescatecholate complexesbiological activityJournal Article10.1016/S0022-328X(03)00585-0