Kilpin, Kelly JoanHenderson, WilliamNicholson, Brian K.2013-12-102013-12-1020082008Kilpin, K. J., Henderson, W., & Nicholson, B. K. (2008). Cycloauration of pyridyl sulfonamides. Dalton Transactions, (29), 3899-3906.https://hdl.handle.net/10289/8314The pyridyl-2-alkylsulfonamides C₅H₄N(CH₂)nNHSO₂R (n = 1,2; R = Me, Ph or p-C6H4Me) and 8-(p-tosylamino)quinoline undergo facile cycloauration reactions with H[AuCl4] in water, giving metallacyclic complexes coordinated through the pyridyl (or quinolyl) nitrogen atom and the deprotonated nitrogen of the sulfonamide group. The complexes have been fully characterised by NMR spectroscopy, ESI mass spectrometry and elemental analysis. The X-ray crystal structures of two derivatives reveal the presence of non-planar sulfonamide nitrogen atoms. The complexes show low activity against P388 murine leukaemia cells, possibly as a result of their ease of reduction with mild reducing agents.enchemistryJournal Article10.1039/b803835j