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      A low-toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures

      Kavtaradze, Levan K.; Manley-Harris, Merilyn; Nicholson, Brian K.
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      DOI
       10.1016/j.steroids.2004.07.003
      Link
       www.elsevier.com
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      Kavtaradze, L.K., Manley-Harris, M. & Nicholson, B.K. (2004). A low toxicity method for the separation of lanosterol and dihydrolanosterol from commercial mixtures. Steroids, 69, 697-700.
      Permanent Research Commons link: https://hdl.handle.net/10289/158
      Abstract
      We describe an inexpensive, low-toxicity and high-yielding method for the production of pure lanosterol and dihydrolanosterol from the commercially available mixture. Optimum conditions are presented for the one-pot production of the intermediate 24,25 vicinal diol of lanosterol acetate (via either epoxidation or hydroxyhalogenation) which is readily separated from the unreacted dihydrolanosterol acetate. The lanosterol diol can then be converted to pure (>97%) lanosterol. Hypophosphorous acid was used for both the conversion of the epoxide to the diol, and as a catalyst for the hydroxyhalogenation by N-halosuccinimides of the olefinic bond.
      Date
      2004-09-01
      Type
      Journal Article
      Publisher
      Elsevier Inc.
      Rights
      This is an authors version of an article published in the journal, Steroids, (c) 2004 Elsevier Inc.
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      • Science and Engineering Papers [3122]
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