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Does Hsp60 provide a link between mitochondrial stress and inflammation in Diabetes Mellitus?

Abstract
The focus of this review is to summarise the known relationships between the expression of Heat Shock Protein 60 (Hsp60) and its association with the pathogenesis of Type 1 and Type 2 Diabetes Mellitus. Hsp60 is a mitochondrial stress protein that is induced by mitochondrial impairment. It is known to be secreted from a number of cell types and circulating levels have been documented in both Type 1 and 2 Diabetes mellitus patients. The biological significance of extracellular Hsp60 however, remains to be established. We will examine the links between Hsp60 and cellular anti and pro- inflammatory processes and specifically address how Hsp60 appears to affect immune inflammation by at least two different mechanisms: as a ligand for innate immune receptors and as an antigen recognized by adaptive immune receptors. We will also look at the role of Hsp60 during immune cell activation in atherosclerosis, a significant risk factor during the pathogenesis of Diabetes Mellitus.
Type
Journal Article
Type of thesis
Series
Citation
Juwono, J., & Martinus, R. D. (2016). Does Hsp60 provide a link between mitochondrial stress and inflammation in Diabetes Mellitus? Journal of Diabetes Research.
Date
2016
Publisher
Hindawi Publishing Corporation
Degree
Supervisors
Rights
This is an author’s accepted version of an article published in the journal: Journal of Diabetes Research. © 2016 Journal of Diabetes Research.