Cycloauration of pyridyl sulphonamides
| dc.contributor.author | Kilpin, Kelly Joan | |
| dc.contributor.author | Henderson, William | |
| dc.contributor.author | Nicholson, Brian K. | |
| dc.coverage.spatial | England | en_NZ |
| dc.date.accessioned | 2009-08-13T01:00:34Z | |
| dc.date.available | 2009-08-13T01:00:34Z | |
| dc.date.issued | 2008 | |
| dc.description.abstract | The pyridyl-2-alkylsulfonamides C₅H₄N(CH₂)nNHSO₂R (n = 1,2; R = Me, Ph or p-C₆H₄Me) and 8-(p-tosylamino)quinoline undergo facile cycloauration reactions with H[AuCl₄] in water, giving metallacyclic complexes coordinated through the pyridyl (or quinolyl) nitrogen atom and the deprotonated nitrogen of the sulfonamide group. The complexes have been fully characterised by NMR spectroscopy, ESI mass spectrometry and elemental analysis. The X-ray crystal structures of two derivatives reveal the presence of non-planar sulfonamide nitrogen atoms. The complexes show low activity against P388 murine leukaemia cells, possibly as a result of their ease of reduction with mild reducing agents. | en |
| dc.format.mimetype | application/pdf | |
| dc.identifier.citation | Kilpin, K. J., Henderson, W. & Nicholson, B. K. (2008). Cycloauration of pyridyl sulphonamides. Dalton Transactions, 29, 3899- 3906. | en |
| dc.identifier.doi | 10.1039/b803835j | en |
| dc.identifier.uri | https://hdl.handle.net/10289/2822 | |
| dc.language.iso | en | |
| dc.publisher | The Royal Society of Chemistry | en_NZ |
| dc.relation.isPartOf | Dalton Transactions | en_NZ |
| dc.rights | This is an author’s accepted version of an article published in the journal: Dalton Transactions. | en |
| dc.subject | Gold | en |
| dc.subject | Metallacycle | en |
| dc.subject | Sulfonamide | en |
| dc.subject | Cycloauration | en |
| dc.subject | Pyridine ligands | en |
| dc.title | Cycloauration of pyridyl sulphonamides | en |
| dc.type | Journal Article | en |
| dspace.entity.type | Publication | |
| pubs.begin-page | 3899 | en_NZ |
| pubs.end-page | 3906 | en_NZ |
| pubs.issue | 29 | en_NZ |
| pubs.volume | 29 | en_NZ |