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The equilibrium model for the effect of temperature on enzymes: Insights and implications

Abstract
A new, experimentally-validated “Equilibrium Model” describes the effect of temperature on enzymes, and provides a new mechanism for the reversible loss of enzyme activity with temperature. It incorporates two new, fundamental parameters that allow a complete description of the effect of temperature on enzyme activity: ΔHeq and Teq. ΔHeq emerges as an intrinsic and quantitative measure of enzyme eurythermal adaptation, while Teq, the equilibrium temperature, has fundamental and technological significance for our understanding of the effect of temperature on enzymatic reactions. For biotechnological purposes, these parameters need to be considered when enzymes are applied or engineered for activity at high temperatures.
Type
Journal Article
Type of thesis
Series
Citation
Weinberg, C. S., Daniel, R. M., Monk, C. R., Danson, M. J. & Lee, C. K. (2008). The equilibrium model for the effect of temperature on enzymes: Insights and implications. Supplement to Chemistry Today-Focus on Biocatatlysts, 26(4), 1-2.
Date
2008
Publisher
Teknoscienze SRL
Degree
Supervisors
Rights
This article has been published in the journal: Supplement to Chemistry Today-Focus on Biocatatlysts. Used with permission.