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dc.contributor.authorKlockars, Anicaen_NZ
dc.contributor.authorWood, Erin L.en_NZ
dc.contributor.authorGartner, Sarah Nicoleen_NZ
dc.contributor.authorMcColl, Laura Kathrynen_NZ
dc.contributor.authorLevine, Allen S.en_NZ
dc.contributor.authorCarpenter, Elizabeth A.en_NZ
dc.contributor.authorProsser, Colin G.en_NZ
dc.contributor.authorOlszewski, Pawel K.en_NZ
dc.coverage.spatialSwitzerlanden_NZ
dc.date.accessioned2019-05-23T03:26:31Z
dc.date.available2019-03-28en_NZ
dc.date.available2019-05-23T03:26:31Z
dc.date.issued2019en_NZ
dc.identifier.citationKlockars, A., Wood, E. L., Gartner, S. N., McColl, L. K., Levine, A. S., Carpenter, E. A., … Olszewski, P. K. (2019). Palatability of Goat’s versus Cow’s Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models. Nutrients, 11(4). https://doi.org/10.3390/nu11040720en
dc.identifier.urihttps://hdl.handle.net/10289/12555
dc.description.abstractGoat's (GM) and cow's milk (CM) are dietary alternatives with select health benefits shown in human and animal studies. Surprisingly, no systematic analysis of palatability or preference for GM vs. CM has been performed to date. Here, we present a comprehensive investigation of short-term intake and palatability profiles of GM and CM in laboratory mice and rats. We studied consumption in no-choice and choice scenarios, including meal microstructure, and by using isocaloric milks and milk-enriched solid diets. Feeding results are accompanied by qPCR data of relevant genes in the energy balance-related hypothalamus and brain stem, and in the nucleus accumbens, which regulates eating for palatability. We found that GM and CM are palatable to juvenile, adult, and aged rodents. Given a choice, animals prefer GM- to CM-based diets. Analysis of meal microstructure using licking patterns points to enhanced palatability of and, possibly, greater motivation toward GM over CM. Most profound changes in gene expression after GM vs. CM were associated with the brain systems driving consumption for reward. We conclude that, while both GM and CM are palatable, GM is preferred over CM by laboratory animals, and this preference is driven by central mechanisms controlling eating for pleasure.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.rightsThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
dc.subjectappetiteen_NZ
dc.subjecthypothalamusen_NZ
dc.subjectmilken_NZ
dc.subjectnucleus accumbensen_NZ
dc.subjectpalatabilityen_NZ
dc.subjectrewarden_NZ
dc.titlePalatability of Goat's versus Cow's Milk: Insights from the Analysis of Eating Behavior and Gene Expression in the Appetite-Relevant Brain Circuit in Laboratory Animal Models.en_NZ
dc.typeJournal Article
dc.identifier.doi10.3390/nu11040720en_NZ
dc.relation.isPartOfNutrientsen_NZ
pubs.elements-id236606
pubs.issue4en_NZ
pubs.publication-statusPublished onlineen_NZ
pubs.volume11en_NZ
dc.identifier.eissn2072-6643en_NZ


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