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dc.contributor.authorLawrenson, Rossen_NZ
dc.contributor.authorLao, Chunhuanen_NZ
dc.contributor.authorCampbell, Ianen_NZ
dc.contributor.authorHarvey, Vernonen_NZ
dc.contributor.authorSeneviratne, Sanjeewaen_NZ
dc.contributor.authorEdwards, Melissaen_NZ
dc.contributor.authorElwood, Marken_NZ
dc.contributor.authorScott, Ninaen_NZ
dc.contributor.authorKidd, Jacquieen_NZ
dc.contributor.authorSarfati, Dianaen_NZ
dc.contributor.authorKuper-Hommel, Marionen_NZ
dc.date.accessioned2019-06-03T23:51:51Z
dc.date.available2017-12-01en_NZ
dc.date.available2019-06-03T23:51:51Z
dc.date.issued2017en_NZ
dc.identifier.citationLawrenson, R., Lao, C., Campbell, I., Harvey, V., Seneviratne, S., Edwards, M., … Kuper-Hommel, M. (2017). Treatment and survival disparities by ethnicity in New Zealand women with stage I-III breast cancer tumour subtypes. Cancer Causes & Control, 28(12), 1417–1427. https://doi.org/10.1007/s10552-017-0969-9en
dc.identifier.issn0957-5243en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/12587
dc.description.abstractPurpose This study aims to look at the distribution of different subtypes of stage I–III breast cancer in Māori and Pacific versus non-Māori/Pacific women, and to examine cancer outcomes by ethnicity within these different subtypes. Method This study included 9,015 women diagnosed with stage I–III breast cancer between June 2000 and May 2013, recorded in the combined Waikato and Auckland Breast Cancer Registers, who had complete data on ER, PR and HER2 status. Five ER/PR/HER2 subtypes were defined. Kaplan–Meier method and Cox proportional hazards model were used to examine ethnic disparities in breast cancer-specific survival. Results Of the 9,015 women, 891 were Māori, 548 were Pacific and 7,576 others. Both Māori and Pacific women were less likely to have triple negative breast cancer compared to others (8.6, 8.9 vs. 13.0%). Pacific women were more than twice as likely to have ER−, PR− and HER2+ cancer than Māori and others (14.2 vs. 6.0%, 6.7%). After adjustment for age, year of diagnosis, stage, grade and treatment, the hazard ratios of breast cancer-specific mortality for Māori and Pacific women with ER+, PR+ and HER2− were 1.52 (95% CI 1.06–2.18) and 1.55 (95% CI 1.04–2.31) compared to others, respectively. Māori women with HER2+ cancer were twice more likely to die of their cancer than others. Conclusions Outcomes for Māori and Pacific women could be improved by better treatment regimens especially for those with HER2+ breast cancer and for women with ER+, PR+ and HER2− breast cancer.
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.publisherSpringeren_NZ
dc.rightsThis is an author’s accepted version of an article published in the journal: Cancer Causes & Control. © 2017 Springer.
dc.subjectScience & Technologyen_NZ
dc.subjectLife Sciences & Biomedicineen_NZ
dc.subjectOncologyen_NZ
dc.subjectPublic, Environmental & Occupational Healthen_NZ
dc.subjectBreast canceren_NZ
dc.subjectSubtypesen_NZ
dc.subjectEthnic disparitiesen_NZ
dc.subjectEstrogen receptoren_NZ
dc.subjectProgesterone receptoren_NZ
dc.subjectHuman epidermal growth factor receptor 2en_NZ
dc.subjectINTERNATIONAL EXPERT CONSENSUSen_NZ
dc.subjectPRIMARY THERAPYen_NZ
dc.subjectRISK-FACTORSen_NZ
dc.subjectMAORI WOMENen_NZ
dc.subjectHIGHLIGHTSen_NZ
dc.subjectMORTALITYen_NZ
dc.titleTreatment and survival disparities by ethnicity in New Zealand women with stage I-III breast cancer tumour subtypesen_NZ
dc.typeJournal Article
dc.identifier.doi10.1007/s10552-017-0969-9en_NZ
dc.relation.isPartOfCancer Causes & Controlen_NZ
pubs.begin-page1417
pubs.elements-id208130
pubs.end-page1427
pubs.issue12en_NZ
pubs.publication-statusPublisheden_NZ
pubs.volume28en_NZ
dc.identifier.eissn1573-7225en_NZ


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