Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Research
      • Computing and Mathematical Sciences
      • Computing and Mathematical Sciences Papers
      • View Item
      •   Research Commons
      • University of Waikato Research
      • Computing and Mathematical Sciences
      • Computing and Mathematical Sciences Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Metaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulator

      Wang, Hongyu; Chepulis, Lynne Merran; Paul, Ryan G.; Mayo, Michael
      Thumbnail
      Files
      s2196888821500111(1).pdf
      Published version, 2.150Mb
      DOI
       10.1142/s2196888821500111
      Find in your library  
      Citation
      Export citation
      Wang, H., Chepulis, L. M., Paul, R. G., & Mayo, M. (2021). Metaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulator. Vietnam Journal of Computer Science, 8(2), 263–290. https://doi.org/10.1142/s2196888821500111
      Permanent Research Commons link: https://hdl.handle.net/10289/14148
      Abstract
      Metaheuristic search algorithms are used to develop new protocols for optimal intravenous insulin infusion rate recommendations in scenarios involving hospital in-patients with Type 1 Diabetes. Two metaheuristic search algorithms are used, namely, Particle Swarm Optimization and Covariance Matrix Adaption Evolution Strategy. The Glucose Regulation for Intensive Care Patients (GRIP) serves as the starting point of the optimization process. We base our experiments on a methodology in the literature to evaluate the favorability of insulin protocols, with a dataset of blood glucose level/insulin infusion rate time series records from 16 patients obtained from the Waikato District Health Board. New and significantly better insulin infusion strategies than GRIP are discovered from the data through metaheuristic search. The newly discovered strategies are further validated and show good performance against various competitive benchmarks using a virtual patient simulator.
      Date
      2021
      Type
      Journal Article
      Publisher
      World Scientific
      Rights
      © The authors. This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
      Collections
      • Computing and Mathematical Sciences Papers [1400]
      Show full item record  

      Usage

       
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement