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dc.contributor.authorWang, Hongyuen_NZ
dc.contributor.authorChepulis, Lynne Merranen_NZ
dc.contributor.authorPaul, Ryan G.en_NZ
dc.contributor.authorMayo, Michaelen_NZ
dc.date.accessioned2021-03-03T01:34:16Z
dc.date.available2021-03-03T01:34:16Z
dc.date.issued2021en_NZ
dc.identifier.citationWang, H., Chepulis, L. M., Paul, R. G., & Mayo, M. (2021). Metaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulator. Vietnam Journal of Computer Science, 8(2), 263–290. https://doi.org/10.1142/s2196888821500111en
dc.identifier.issn2196-8888en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/14148
dc.description.abstractMetaheuristic search algorithms are used to develop new protocols for optimal intravenous insulin infusion rate recommendations in scenarios involving hospital in-patients with Type 1 Diabetes. Two metaheuristic search algorithms are used, namely, Particle Swarm Optimization and Covariance Matrix Adaption Evolution Strategy. The Glucose Regulation for Intensive Care Patients (GRIP) serves as the starting point of the optimization process. We base our experiments on a methodology in the literature to evaluate the favorability of insulin protocols, with a dataset of blood glucose level/insulin infusion rate time series records from 16 patients obtained from the Waikato District Health Board. New and significantly better insulin infusion strategies than GRIP are discovered from the data through metaheuristic search. The newly discovered strategies are further validated and show good performance against various competitive benchmarks using a virtual patient simulator.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoenen_NZ
dc.publisherWorld Scientificen_NZ
dc.rights© The authors. This is an Open Access article published by World Scientific Publishing Company. It is distributed under the terms of the Creative Commons Attribution 4.0 (CC BY) License which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
dc.subjectcomputer scienceen_NZ
dc.subjectmetaheuristic searchen_NZ
dc.subjectcontinuous optimisationen_NZ
dc.subjectinsulin infusion protocolen_NZ
dc.subjectsimulated validationen_NZ
dc.titleMetaheuristic optimization of insulin infusion protocols using historical data with validation using a patient simulatoren_NZ
dc.typeJournal Article
dc.identifier.doi10.1142/s2196888821500111en_NZ
dc.relation.isPartOfVietnam Journal of Computer Scienceen_NZ
pubs.begin-page263
pubs.elements-id259815
pubs.end-page290
pubs.issue2en_NZ
pubs.publication-statusPublished onlineen_NZ
pubs.volume8en_NZ
dc.identifier.eissn2196-8896en_NZ


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