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      The sleep cycle modelled as a cortical phase transition

      Steyn-Ross, D. Alistair; Steyn-Ross, Moira L.; Sleigh, James W.; Wilson, Marcus T.; Gillies, Iain-Patrick; Wright, J. J.
      DOI
       10.1007/s10867-005-1285-2
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      Steyn-Ross, D. A., Steyn-Ross, M. L., Sleigh, J. W., Wilson, M. T., Gillies, I. P. & Wright, J. J. (2005). The sleep cycle modelled as a cortical phase transition. Journal of Biological Physics, 31(3/4), 547- 569.
      Permanent Research Commons link: https://hdl.handle.net/10289/1420
      Abstract
      We present a mean-field model of the cortex that attempts to describe the gross changes in brain electrical activity for the cycles of natural sleep. We incorporate within the model two major sleep modulatory effects: slow changes in both synaptic efficiency and in neuron resting voltage caused by the ∼90-min cycling in acetylcholine, together with even slower changes in resting voltage caused by gradual elimination during sleep of somnogens (fatigue agents) such as adenosine. We argue that the change from slow-wave sleep (SWS) to rapid-eye-movement (REM) sleep can be understood as a first-order phase transition from a low-firing, coherent state to a high-firing, desychronized cortical state. We show that the model predictions for changes in EEG power, spectral distribution, and correlation time at the SWS-to-REM transition are consistent not only with those observed in clinical recordings of a sleeping human subject, but also with the on-cortex EEG patterns recently reported by Destexhe et al. [J. Neurosci. 19(11), (1999) 4595–4608] for the sleeping cat.
      Date
      2005-12
      Type
      Journal Article
      Publisher
      SPRINGER
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      • Science and Engineering Papers [2525]
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