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dc.contributor.authorWilson, Marcus T.en_NZ
dc.contributor.authorGoldsworthy, Mitchell R.en_NZ
dc.contributor.authorVallence, Ann-Mareeen_NZ
dc.contributor.authorFornito, Alexen_NZ
dc.contributor.authorRogasch, Nigel C.en_NZ
dc.coverage.spatialNetherlandsen_NZ
dc.date.accessioned2023-11-10T02:33:24Z
dc.date.available2023-11-10T02:33:24Z
dc.date.issued2023-02-15en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/16128
dc.description.abstractOBJECTIVE: We aimed to use measured input-output (IO) data to identify the best fitting model for motor evoked potentials. METHODS: We analyzed existing IO data before and after intermittent and continuous theta-burst stimulation (iTBS & cTBS) from a small group of subjects (18 for each). We fitted individual synaptic couplings and sensitivity parameters using variations of a biophysical model. A best performing model was selected and analyzed. RESULTS: cTBS gives a broad reduction in MEPs for amplitudes larger than resting motor threshold (RMT). Close to threshold, iTBS gives strong potentiation. The model captures individual IO curves. There is no change to the population average synaptic weights post TBS but the change in excitatory-to-excitatory synaptic coupling is strongly correlated with the experimental post-TBS response relative to baseline. CONCLUSIONS: The model describes population-averaged and individual IO curves, and their post-TBS change. Variation among individuals is accounted for with variation in synaptic couplings, and variation in sensitivity of neural response to stimulation. SIGNIFICANCE: The best fitting model could be applied more broadly and validation studies could elucidate underlying biophysical meaning of parameters.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoengen_NZ
dc.publisherElsevier B.V.
dc.rightsThis is an author’s accepted version of an article published in Brain Research. © 2023 Elsevier B.V.
dc.subjectCortical plasticityen_NZ
dc.subjectModelingen_NZ
dc.subjectMotor evoked potentialen_NZ
dc.subjectNeural field theoryen_NZ
dc.subjectTheta burst stimulationen_NZ
dc.subjectTranscranial magnetic stimulationen_NZ
dc.subjectHumansen_NZ
dc.subjectNeuronal Plasticityen_NZ
dc.subjectTranscranial Magnetic Stimulationen_NZ
dc.subjectEvoked Potentials, Motoren_NZ
dc.subjectMotor Cortexen_NZ
dc.subjectBiophysicsen_NZ
dc.subjectTheta Rhythmen_NZ
dc.titleFinding synaptic couplings from a biophysical model of motor evoked potentials after theta-burst transcranial magnetic stimulationen_NZ
dc.typeJournal Article
dc.identifier.doi10.1016/j.brainres.2022.148205en_NZ
dc.relation.isPartOfBrain Resen_NZ
pubs.begin-page148205
pubs.elements-id302327
pubs.publication-statusPublisheden_NZ
pubs.volume1801en_NZ
dc.identifier.eissn1872-6240en_NZ


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