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      Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand

      Nicholson, Brian K.; Henderson, William; Dinger, Maarten B.
      DOI
       10.1016/S0020-1693(03)00298-6
      Link
       www.sciencedirect.com.ezproxy.waikato.ac.nz:2048
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      Nicholson, B. K., Henderson, W. & Dinger, M.B. (2003). Synthesis and crystal structure of the first complex containing a chelating selenourea dianion ligand. Inorganica Chimica Acta, 355, 428-431.
      Permanent Research Commons link: https://hdl.handle.net/10289/198
      Abstract
      Reaction of N,N′-diphenylselenourea, PhNHC(Se)NHPh, with cis-[PtCl2(PPh3)2] and triethylamine in hot methanol gives the first example of a selenourea dianion complex, [Pt{SeC(=NPh)NPh}(PPh3)2] isolated as a yellow solid in high yield. The structure of the complex was determined by X-ray crystallography and found to be similar to the related thiourea dianion complex [Pt{SC(=NPh)NPh}(PPh3)2], with a Pt---Se---C---N four-membered ring. The antitumour activity (P388 murine leukaemia cells) of the selenourea dianion complex was determined, together with a small selection of related platinum(II)-thiourea dianion complexes (prepared by an analogous method) for comparison. The complex [Pt{SC(=NMe)NMe}(PPh3)2] showed high activity [IC50 1.0 μM], with the other complexes showing moderate to low activity.
      Date
      2003-11-01
      Type
      Journal Article
      Publisher
      Elsevier
      Rights
      This article is published in the journal Inorganica Chimica Acta, (c) 2003 Elsevier B.V.
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      • Science and Engineering Papers [3143]
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