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dc.contributor.authorWorth, Andrew J.
dc.contributor.authorMucalo, Michael R.
dc.contributor.authorHorne, Geoffrey
dc.contributor.authorBruce, Warrick
dc.contributor.authorBurbridge, Hilary
dc.date.accessioned2009-05-20T02:17:22Z
dc.date.available2009-05-20T02:17:22Z
dc.date.issued2005
dc.identifier.citationWorth, A., Mucalo, M., Horne, G., Bruce, W. & Burbidge, H. (2005). The evaluation of processed cancellous bovine bone as a bone graft substitute. Clinical Oral Implants Research, 16(3), 379-386.en
dc.identifier.urihttps://hdl.handle.net/10289/2169
dc.description.abstractObjective: To determine the ability of a novel bovine cancellous bone xenoimplant to act as an osteoconductive graft in an ovine femoral defect model. An autograft harvested from the xenoimplant site was placed in a contralateral limb defect for comparison. Material and methods: The xenoimplant used had been rendered immunologically inert by a novel defatting and deproteinating process. Following surgical implantation of cores into condylar cancellous bone defects, fluorochrome labels were administered to 12 sheep at 2 1/2, 4 1/2 and 8 weeks. Incorporation of the xenoimplants and autografts into the host bone was compared radiographically and histomorphometrically at 10 weeks. Results: Radiographically, the degree of osteointegration was comparable. Histomorphometric data, consisting of labelled surface (LS) estimates, confirmed osteoconductive properties of both the xenoimplants and autografts. Remodelling activity was greatest in the xenoimplants at 2 1/2, weeks. At 4 1/2 weeks, there was more activity in the autograft, but by 8 weeks they were performing similarly. Xenoimplant-LS estimates were comparable or greater than those of the autograft at all times. Conclusions: Processed bovine cancellous bone xenoimplants were osteoconductive in this model and show promise for development as a biomaterial in human and veterinary orthopaedic surgery.en
dc.language.isoen
dc.publisherBlackwell Munksgaarden_NZ
dc.relation.urihttp://www3.interscience.wiley.com/journal/118702324/abstract?CRETRY=1&SRETRY=0en
dc.subjectbiomaterialsen
dc.subjectbovine hydroxyapatiteen
dc.subjectcomposite bone graftingen
dc.subjecthistomorphometryen
dc.subjectovine condylar defecten
dc.subjectxenograftingen
dc.subjectxenoimplanten
dc.titleThe evaluation of processed cancellous bovine bone as a bone graft substituteen
dc.typeJournal Articleen
dc.identifier.doi10.1111/j.1600-0501.2005.01113.xen
dc.relation.isPartOfClinical Oral Implant Researchen_NZ
pubs.begin-page379en_NZ
pubs.editionJuneen_NZ
pubs.elements-id30809
pubs.end-page386en_NZ
pubs.issue3en_NZ
pubs.volume16en_NZ


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