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      Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula

      Tripathi, Ashootosh; Puddick, Jonathan; Prinsep, Michèle R.; Lee, Peter Peng Foo; Tan, Lik Tong
      DOI
       10.1021/np800448t
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      Tripathi, A., Puddick, J., Prinsep, M.R., Lee, P.P.F. & Tan, L.T. (2009). Hantupeptin A, a cytotoxic cyclic depsipeptide from a Singapore collection of Lyngbya majuscula. Journal of Natural Products, 72(1), 29-32.
      Permanent Research Commons link: https://hdl.handle.net/10289/2219
      Abstract
      Chemical investigation of the marine cyanobacterium Lyngbya majuscula from Pulau Hantu Besar, Singapore, has led to the isolation of a cyclodepsipeptide, hantupeptin A (1). The planar structure of 1 was assigned on the basis of extensive 1D and 2D NMR spectroscopic experiments. The absolute configuration of the amino and hydroxyl acid residues in the molecule was determined by application of the advanced Marfey method, chiral HPLC analysis, and Mosher’s method. Hantupeptin A showed cytotoxicity to MOLT-4 leukemia cells and MCF-7 breast cancer cells with IC50 values of 32 and 4.0 µM, respectively.
      Date
      2009
      Type
      Journal Article
      Publisher
      American Chemical Society
      Collections
      • Science and Engineering Papers [3119]
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