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      Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands

      Kilpin, Kelly Joan; Henderson, William; Nicholson, Brian K.
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      Henderson et al - Synthesis and reactivity of gold.pdf
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      DOI
       10.1016/j.ica.2009.04.024
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      Kilpin, K. J., Henderson, W. & Nicholson, B. K. (2009). Synthesis and reactivity of gold(III) complexes containing cycloaurated iminophosphorane ligands. Inorganica Chimica Acta, 362(10), 3669-3676.
      Permanent Research Commons link: https://hdl.handle.net/10289/3354
      Abstract
      Transmetallation reactions of ortho-mercurated iminophosphoranes (2-ClHgC₆H₄)Ph₂P NR with [AuCl₄]⁻ gives new cycloaurated iminophosphorane complexes of gold(III) (2-Cl₂AuC₆H₄)Ph₂P NR [R = (R,S)- or (S)-CHMePh, p-C₆H₄F, tBu], characterised by NMR and IR spectroscopies, ESI mass spectrometry and an X-ray structure determination on the chiral derivative R = (S)-CHMePh. The chloride ligands of these complexes can be readily replaced by the chelating ligands thiosalicylate and catecholate; the resulting derivatives show markedly higher anti-tumour activity versus P388 murine leukaemia cells compared to the parent chloride complexes. Reaction of (2-Cl₂AuC₆H₄)Ph₂P NPh with PPh₃ results in displacement of a chloride ligand giving the cationic complex [(2-Cl(PPh₃)AuC₆H₄)Ph₂P NPh]⁺, indicating that the P N donor is strongly bonded to the gold centre.
      Date
      2009
      Type
      Journal Article
      Publisher
      Elsevier
      Rights
      This is an author’s accepted version of an article published in the journal: Inorganica Chimica Acta. Used with permission.
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      • Science and Engineering Papers [3143]
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