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      Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus

      Han, Sangmi; Yeo, Joohong; Baek, Haju; Lin, Shih-Min (Sam); Meyer, Stacy; Molan, Peter C.
      DOI
       10.1080/10286020903164277
      Link
       www.informaworld.com
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      Han, S., Yeo, J., Baek, H., Lin, S.-M., Meyer, S. & Molan, P. (2009). Postantibiotic effect of purified melittin from honeybee (Apis mellifera) venom against Escherichia coli and Staphylococcus aureus. Journal of Asian Natural Products Research, 11(9), 796-804.
      Permanent Research Commons link: https://hdl.handle.net/10289/4107
      Abstract
      Since the ancient times, the antibacterial application of honeybee venom (BV) has been practised and persisted. We investigated the antibacterial activity of whole BV and purified melittin against Escherichia coli and Staphylococcus aureus by the minimum inhibitory concentrations (MICs) and the postantibiotic effects (PAEs). The in vitro PAEs of whole BV and isolated melittin were determined using E. coli and S. aureus. The PAEs of whole BV against E. coli and S. aureus were 0.15 h (1 MIC), 2.4 h (5 MIC), and 3.45 h (1 MIC), respectively. The PAEs of melittin against E. coli and S. aureus were 0.1 h (1 MIC), 3.2 h (5 MIC), and 4.35 h (1 MIC), respectively. These results suggest that whole BV and melittin will be developed as a novel antibacterial drug.
      Date
      2009
      Type
      Journal Article
      Publisher
      Taylor & Francis Group
      Collections
      • Science and Engineering Papers [3116]
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