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      The thermal behaviour of enzyme activity: implications for biotechnology

      Eisenthal, Robert; Peterson, Michelle E.; Daniel, Roy M.; Danson, Michael J.
      DOI
       10.1016/j.tibtech.2006.05.004
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      Eisenthal, R., Peterson, M.E., Daniel, R.M. & Danson, M.J. (2006). The thermal behaviour of enzyme activity: implications for biotechnology. Trends in Biotechnology, 24(7), 289-292.
      Permanent Research Commons link: https://hdl.handle.net/10289/4442
      Abstract
      The way that enzymes respond to temperature is fundamental to many areas of biotechnology. This has long been explained in terms of enzyme stability and catalytic activation energy, but recent observations of enzyme behaviour suggest that this picture is incomplete. We have developed and experimentally validated a new model to describe the effect of temperature on enzymes; this model incorporates additional fundamental parameters that enable a complete description of the effects of temperature on enzyme activity. In this article, we consider the biotechnological implications of this model in the areas of enzyme engineering, enzyme reactor operation and the selection and/or screening of useful enzymes from the environment.
      Date
      2006
      Type
      Journal Article
      Publisher
      Elsevier
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      • Science and Engineering Papers [3124]
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