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      Did primitive microorganisms use nonhem iron proteins in place of NAD/P?

      Daniel, Roy M.; Danson, Michael J.
      DOI
       10.1007/BF00160501
      Link
       www.springerlink.com
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      Citation
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      Daniel, R. M. & Danson, M.J. (1995). Did primitive microorganisms use nonhem iron proteins in place of NAD/P? Journal of Molecular Evolution, 40(6), 559-563.
      Permanent Research Commons link: https://hdl.handle.net/10289/4476
      Abstract
      Nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP) are of universal occurrence in living organisms and play a central role in coupling oxidative with reductive reactions. However, the evidence that the origin and early evolution of life occurred at high temperatures (>95°C) is now strong, and at these temperatures some modern metabolites, including both the reduced and oxidized forms of these coenzymes, are unstable. We believe there is good evidence that indicates that in the most primitive organisms nonhem iron proteins carried out many or all of the functions of NAD/P(H). This has important implications for the way in which investigations of archaebacterial metabolism are conducted.
      Date
      1995
      Type
      Journal Article
      Publisher
      Springer
      Collections
      • Science and Engineering Papers [3124]
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