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MALDI-TOF mass spectrometry of Cyanobacteria: a global approach to the discovery of novel secondary metabolites

Abstract
Cyanobacteria (blue-green algae) are a group of ancient prokaryotic organisms dating back between three and four billion years.¹ They have been attributed with oxygenating the earth’s atmosphere² but, since the anthropogenic euthrophication of lakes, ponds and oceans, they have become synonymous with water hygiene issues.³ This is due to the alteration of the nutrient composition of their habitat to one which is optimal for growth (or blooms). Cyanobacterial blooms may simply cause foul tastes and odours,⁴ but they can also lead to the production of toxic secondary metabolites poisonous to humans and animals upon ingestion.⁵ NZ has yet to suffer a human fatality, but the deaths of several dogs in Wellington was attributed to homoanatoxin-a 1 (Chart 1) from a Phormidium species.⁶
Type
Journal Article
Type of thesis
Series
Citation
Puddick, J. & Prinsep, M.R. (2008). MALDI-TOF mass spectrometry of Cyanobacteria: a global approach to the discovery of novel secondary metabolites. Chemistry in New Zealand, 72(2), 68-71.
Date
2008
Publisher
New Zealand Institute of Chemistry
Degree
Supervisors
Rights
This article has been published in the journal: Chemistry in New Zealand. Used with permission.