Loading...
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors
Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviors
Abstract
Large-scale synchronous firing of neurons during seizures is modulated by electrotonic coupling between neurons via gap junctions. To explore roles for connexin36 (Cx36) gap junctions in seizures, we examined the seizure threshold of connexin36 knockout (Cx36KO) mice using a pentylenetetrazol (PTZ) model.
Type
Journal Article
Type of thesis
Series
Citation
Jacobson, G.M., Voss, L.J., Melin, S.M., Mason, J.P., Cursons, R.T.,…, Sleigh, J.W. (2010). Connexin36 knockout mice display increased sensitivity to pentylenetetrazol-induced seizure-like behaviours. Brain Research, 1360(11), 198-204.
Date
2010
Publisher
Elsevier
Degree
Supervisors
Rights
This is an author’s accepted version of an article published in the journal: Brain Research. © 2010 Elsevier.