Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom
Moldes-Anaya, A., Rundberget, T., Uhlig, S., Rise, F. & Wilkins, A.L. (2010). Isolation and structure elucidation of secopenitrem D, an indole alkaloid from Penicillium crustosum Thom. Toxicon, available online on 8 December 2010.
Permanent Research Commons link: https://hdl.handle.net/10289/4882
Chemical investigation of three isolates of Penicillium crustosum Thom cultures, one of which was derived from a recent dog poisoning investigation, has led to the isolation and structure elucidation of secopenitrem D (1). Penitrems A-F and roquefortine C were also present in the isolates analyzed. The structure of 1 was unambiguously assigned based on extensive 1D- and 2D-NMR spectroscopic experiments, MS-aided structural studies and by comparison with structurally related congeners. Secopenitrem D lacks the C-16−C-18 ether linkage present in penitrems A-F.