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      Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscula

      Tripathi, Ashootosh; Puddick, Jonathan; Prinsep, Michèle R.; Lee, Peter Peng Foo; Tan, Lik Tong
      DOI
       10.1016/j.phytochem.2009.10.006
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      Tripathi, A., Puddick, J., Prinsep, M.R., Lee, P.P.F. & Tan, L.T. (2010). Hantupeptins B and C, cytotoxic cyclodepsipeptides from the marine cyanobacterium Lyngbya majuscule. Phytochemistry, 71(2-3), 307-311.
      Permanent Research Commons link: https://hdl.handle.net/10289/4900
      Abstract
      Hantupeptins B (2) and C (3) were isolated, along with the previously reported hantupeptin A (1), from the marine cyanobacterium, Lyngbya majuscula, collected from Pulau Hantu Besar, Singapore. Their structures were elucidated by interpretation of extensive 1D and 2D NMR spectroscopic data. Compounds 2 and 3 are cyclic depsipeptides consisting of five α-amino/hydroxy acid residues, including phenyllactic acid, proline, N-methyl-valine, valine, N-methyl-isoleucine, and a β-hydroxy acid unit with different degrees of unsaturation at the terminal end of each molecule. The absolute configurations of the common amino acids and phenyllactic acid were determined by the advanced Marfey’s and chiral HPLC analyses, respectively. The complete stereochemistry of 3-hydroxy-2-methyl-7-octynoic acid moiety in hantupeptin A was elucidated by a combination of homonuclear J-resolved 2D NMR experiments and by Mosher’s method. Hantupeptins B and C showed moderate in vitro cytotoxicity when tested against MOLT-4 (leukemic) and MCF-7 (breast cancer) cell lines.
      Date
      2010-02
      Type
      Journal Article
      Publisher
      Elsevier
      Collections
      • Science and Engineering Papers [3122]
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