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dc.contributor.authorSteyn-Ross, Moira L.
dc.contributor.authorSteyn-Ross, D. Alistair
dc.contributor.authorSleigh, James W.
dc.contributor.authorWilson, Marcus T.
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2011-03-28T22:51:29Z
dc.date.available2011-03-28T22:51:29Z
dc.date.issued2011
dc.identifier.citationSteyn-Ross, M.L., Steyn-Ross, D.A., Sleigh, J.W. & Wilson, M.T. (2011). A mechanism for ultra-slow oscillations in the cortical default network. Bulletin of Mathematical Biology, 73(2), 398-416.en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/5207
dc.description.abstractWhen the brain is in its noncognitive “idling” state, functional MRI measurements reveal the activation of default cortical networks whose activity is suppressed during cognitive processing. This default or background mode is characterized by ultra-slow BOLD oscillations (∼0.05 Hz), signaling extremely slow cycling in cortical metabolic demand across distinct cortical regions. Here we describe a model of the cortex which predicts that slow cycling of cortical activity can arise naturally as a result of nonlinear interactions between temporal (Hopf) and spatial (Turing) instabilities. The Hopf instability is triggered by delays in the inhibitory postsynaptic response, while the Turing instability is precipitated by increases in the strength of the gap-junction coupling between interneurons.We comment on possible implications for slow dendritic computation and information processing.en_NZ
dc.language.isoen
dc.publisherSpringerLinken_NZ
dc.relation.urihttp://www.springerlink.com/content/tpkp672102731126/en_NZ
dc.subjectdefault networken_NZ
dc.subjectultra-slow oscillationsen_NZ
dc.subjectcortical idlingen_NZ
dc.subjectTuringen_NZ
dc.subjectHopfen_NZ
dc.subjectspatiotemporal instabilityen_NZ
dc.subjectspatiotemporal instabilityen_NZ
dc.subjecttwo Turingen_NZ
dc.subjectHopf bifurcationen_NZ
dc.titleA mechanism for ultra-slow oscillations in the cortical default networken_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1007/s11538-010-9565-9en_NZ
dc.relation.isPartOfBulletin of Mathematical Biologyen_NZ
pubs.begin-page398en_NZ
pubs.elements-id35820
pubs.end-page416en_NZ
pubs.issue2en_NZ
pubs.volume73en_NZ


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