Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice

      Jacobson, Gregory M.; Voss, Logan J.; Melin, Sofia M.; Cursons, Raymond T.; Sleigh, James W.
      DOI
       10.1111/j.1365-2044.2011.06658.x
      Link
       onlinelibrary.wiley.com
      Find in your library  
      Citation
      Export citation
      Jacobson, G.M., Voss, L.J., Melin, S.M., Cursons, R.T. & Sleigh, J.W. (2011). The role of connexin36 gap junctions in modulating the hypnotic effects of isoflurane and propofol in mice. Anaesthesia, available online 18 March 2011.
      Permanent Research Commons link: https://hdl.handle.net/10289/5209
      Abstract
      Gap junction blockade is a possible mechanism by which general anaesthetic drugs cause unconsciousness. We measured the sensitivity of connexin36 knockout mice to the hypnotic effects of isoflurane and propofol. The experimental endpoint was recovery of the righting reflex of the anaesthetised animals during 0.2% step-reductions in isoflurane concentration, or following intraperitoneal injection of propofol (100 mg.kg⁻¹). Connexin36 knockout animals were more sensitive to the hypnotic effects of isoflurane than ‘normal’ wild-type animals. The half maximal effective concentration (EC50) for recovery of righting reflex was 0.37% for connexin36 knockout vs 0.49% for wild-type animals (p < 0.001). For propofol, connnexin36 knockout animals showed more rapid loss of righting reflex than wild-type animals (mean (SD) 2.8 (0.13) vs 3.8 (0.27) min); and young (< 60 days) connexin36 knockout animals remained anaesthetised for longer than young wild-type mice (47.2 (2.9) vs 30.5 (1.7) min; p < 0.00001). These findings suggest that the hypnotic effects of anaesthetic drugs may be moderately enhanced by gap junction blockade.
      Date
      2011
      Type
      Journal Article
      Rights
      This is an author’s accepted version of an article published in the journal: Asian Christian Review. Used with permission.
      Collections
      • Science and Engineering Papers [3071]
      Show full item record  

      Usage

       
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement