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      The effect of complement C5a on mitochondrial functions of PC12 cells

      Martinus, Ryan Dennis; Cook, Christian J.
      DOI
       10.1097/WNR.0b013e32834901d9
      Link
       journals.lww.com
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      Citation
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      Martinus, R. & Cook, C. (2011). The effect of complement C5a on mitochondrial functions of PC12 cells. Neuroreport, 22(2), 581-585.
      Permanent Research Commons link: https://hdl.handle.net/10289/5494
      Abstract
      C5a is thought to play a role during complement-activated neuronal apoptotic cell death in the central nervous system. The mechanisms responsible are however not well-understood. As mitochondria play a key role during apoptosis, we investigated mitochondria as a potential target for C5a. Using PC12 cells, we demonstrated that exposure to C5a led to inhibition of mitochondrial respiration, dehydrogenase and cytochrome c oxidase activities. Interestingly, an increase in expression of the mitochondrial stress protein chaperonin 60 was also observed, confirming a marked effect of C5a on mitochondrial functions. These observations are the first documented intracellular effects noted for the complement molecule C5a in in-vitro cultured cells.
      Date
      2011-08
      Type
      Journal Article
      Publisher
      Lippincott Williams & Wilkins
      Collections
      • Science and Engineering Papers [3124]
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