Show simple item record  

dc.contributor.authorSteyn-Ross, Moira L.
dc.contributor.authorSteyn-Ross, D. Alistair
dc.contributor.authorSleigh, James W.
dc.coverage.spatialNetherlandsen_NZ
dc.date.accessioned2012-11-05T03:30:38Z
dc.date.available2012-11-05T03:30:38Z
dc.date.copyright2012-06-02
dc.date.issued2012
dc.identifier.citationSteyn-Ross, M. L., Steyn-Ross, D. A., & Sleigh, J. W. (2012). Gap junctions modulate seizures in a mean-field model of general anesthesia for the cortex. Cognitive Neurodynamics, 6(3), 215-225.en_NZ
dc.identifier.issn1871-4048
dc.identifier.urihttps://hdl.handle.net/10289/6794
dc.description.abstractDuring slow-wave sleep, general anesthesia, and generalized seizures, there is an absence of consciousness. These states are characterized by low-frequency large-amplitude traveling waves in scalp electroencephalogram. Therefore the oscillatory state might be an indication of failure to form coherent neuronal assemblies necessary for consciousness. A generalized seizure event is a pathological brain state that is the clearest manifestation of waves of synchronized neuronal activity. Since gap junctions provide a direct electrical connection between adjoining neurons, thus enhancing synchronous behavior, reducing gap-junction conductance should suppress seizures; however there is no clear experimental evidence for this. Here we report theoretical predictions for a physiologically-based cortical model that describes the general anesthetic phase transition from consciousness to coma, and includes both chemical synaptic and direct electrotonic synapses. The model dynamics exhibits both Hopf (temporal) and Turing (spatial) instabilities; the Hopf instability corresponds to the slow ([≲8 Hz) oscillatory states similar to those seen in slow-wave sleep, general anesthesia, and seizures. We argue that a delicately balanced interplay between Hopf and Turing modes provides a canonical mechanism for the default non-cognitive rest state of the brain. We show that the Turing mode, set by gap-junction diffusion, is generally protective against entering oscillatory modes; and that weakening the Turing mode by reducing gap conduction can release an uncontrolled Hopf oscillation and hence an increased propensity for seizure and simultaneously an increased sensitivity to GABAergic anesthesia.en_NZ
dc.language.isoen
dc.publisherSpringer-Verlagen_NZ
dc.relation.ispartofCognitive Neurodynamics
dc.subjectgap junctionsen_NZ
dc.subjectHopf oscillationsen_NZ
dc.subjectmean-field cortical modelen_NZ
dc.subjectnonlinear interactionsen_NZ
dc.subjectphase coherenceen_NZ
dc.subjectseizureen_NZ
dc.subjectTuring patternsen_NZ
dc.titleGap junctions modulate seizures in a mean-field model of general anesthesia for the cortexen_NZ
dc.typeJournal Articleen_NZ
dc.identifier.doi10.1007/s11571-012-9194-0en_NZ
dc.relation.isPartOfCognitive Neurodynamicsen_NZ
pubs.begin-page215en_NZ
pubs.elements-id38396
pubs.end-page225en_NZ
pubs.issue3en_NZ
pubs.volume6en_NZ


Files in this item

FilesSizeFormatView

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record