Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      In vitro electrical conductivity of seizing and non-seizing mouse brain slices at 10 kHz

      Elbohouty, Maher; Wilson, Marcus T.; Voss, Logan J.; Steyn-Ross, D. Alistair; Hunt, Lynette Anne
      DOI
       10.1088/0031-9155/58/11/3599
      Find in your library  
      Citation
      Export citation
      Elbohouty, M., Wilson, M. T., Voss, L. J., Steyn-Ross, D. A., & Hunt, L. A. (2013). In vitro electrical conductivity of seizing and non-seizing mouse brain slices at 10 kHz.. Physics in Medicine and Biology, 58(11), 3599-3613.
      Permanent Research Commons link: https://hdl.handle.net/10289/7600
      Abstract
      The electrical conductivity of small samples of mouse cortex (in vitro) has been measured at 10 kHz through the four-electrode method of van der Pauw. Brain slices from three mice were prepared under seizing and non-seizing conditions by changing the concentration of magnesium in the artificial cerebrospinal fluid used to maintain the tissue. These slices provided 121 square samples of cortical tissue; the conductivity of these samples was measured with an Agilent E4980A four-point impedance monitor. Of these, 73 samples were considered acceptable on the grounds of having good electrical contact between electrodes and tissue excluding outlier measurements. Results show that there is a significant difference (p = 0.03) in the conductivities of the samples under the two conditions. The seizing and non-seizing samples have mean conductivities of 0.33 and 0.36 S m⁻¹, respectively; however, these quantitative values should be used with caution as they are both subject to similar systematic uncertainties due to non-ideal temperature conditions and non-ideal placement of electrodes. We hypothesize that the difference between them, which is more robust to uncertainty, is due to the changing gap junction connectivity during seizures.
      Date
      2013
      Type
      Journal Article
      Publisher
      Institute of Physics
      Collections
      • Computing and Mathematical Sciences Papers [1455]
      • Science and Engineering Papers [3124]
      Show full item record  

      Usage

       
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement