dc.contributor.author | Elbohouty, Maher | |
dc.contributor.author | Wilson, Marcus T. | |
dc.contributor.author | Voss, Logan J. | |
dc.contributor.author | Steyn-Ross, D. Alistair | |
dc.contributor.author | Hunt, Lynette Anne | |
dc.date.accessioned | 2013-05-09T03:05:19Z | |
dc.date.available | 2013-05-09T03:05:19Z | |
dc.date.copyright | 2013-06-07 | |
dc.date.issued | 2013 | |
dc.identifier.citation | Elbohouty, M., Wilson, M. T., Voss, L. J., Steyn-Ross, D. A., & Hunt, L. A. (2013). In vitro electrical conductivity of seizing and non-seizing mouse brain slices at 10 kHz.. Physics in Medicine and Biology, 58(11), 3599-3613. | en_NZ |
dc.identifier.issn | 0031-9155 | |
dc.identifier.uri | https://hdl.handle.net/10289/7600 | |
dc.description.abstract | The electrical conductivity of small samples of mouse cortex (in vitro) has been measured at 10 kHz through the four-electrode method of van der Pauw. Brain slices from three mice were prepared under seizing and non-seizing conditions by changing the concentration of magnesium in the artificial cerebrospinal fluid used to maintain the tissue. These slices provided 121 square samples of cortical tissue; the conductivity of these samples was measured with an Agilent E4980A four-point impedance monitor. Of these, 73 samples were considered acceptable on the grounds of having good electrical contact between electrodes and tissue excluding outlier measurements. Results show that there is a significant difference (p = 0.03) in the conductivities of the samples under the two conditions. The seizing and non-seizing samples have mean conductivities of 0.33 and 0.36 S m⁻¹, respectively; however, these quantitative values should be used with caution as they are both subject to similar systematic uncertainties due to non-ideal temperature conditions and non-ideal placement of electrodes. We hypothesize that the difference between them, which is more robust to uncertainty, is due to the changing gap junction connectivity during seizures. | en_NZ |
dc.language.iso | en | |
dc.publisher | Institute of Physics | en_NZ |
dc.relation.ispartof | Physics in Medicine and Biology | |
dc.subject | electrical conductivity | en_NZ |
dc.subject | cortical tissue | en_NZ |
dc.title | In vitro electrical conductivity of seizing and non-seizing mouse brain slices at 10 kHz | en_NZ |
dc.type | Journal Article | en_NZ |
dc.identifier.doi | 10.1088/0031-9155/58/11/3599 | en_NZ |