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      Isolation and identification of a cis-C₈-diol-ester of okadaic acid from Dinophysis acuta in New Zealand

      Miles, Christopher O.; Wilkins, Alistair L.; Hawkes, Allan D.; Jensen, Dwayne J.; Cooney, Janine M.; Larsen, Kristofer; Petersen, Dirk; Rise, Frode; Beuzenberg, Veronica; Lincoln MacKenzie, A.
      DOI
       10.1016/j.toxicon.2006.04.018
      Link
       www.sciencedirect.com
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      Citation
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      Miles, C. O., Wilkins, A. L., Hawkes, A. D., Jensen, D. J., Cooney, J. M., Larsen, K., Petersen, D., et al. (2006). Isolation and identification of a cis-C8-diol-ester of okadaic acid from Dinophysis acuta in New Zealand. Toxicon, 48(2), 195-203.
      Permanent Research Commons link: https://hdl.handle.net/10289/8400
      Abstract
      A cis-isomer of a C8-diol ester of okadaic acid (1) was isolated during large-scale purification of pectenotoxins (PTXs) from extracts of Dinophysis acuta collected from the west coast of South Island, New Zealand. The compound was identified by NMR spectroscopic and liquid chromatography-mass spectrometry (LC-MS) studies, and is the first reported cis-isomer of an okadaic acid C₈-diol-ester identified in Dinophysis. The more abundant trans-C₈-diol ester of okadaic acid (2) isolated from the same Dinophysis extract was rapidly hydrolyzed to okadaic acid in vitro by the supernatant from green-lipped mussel hepatopancreas.
      Date
      2006
      Type
      Journal Article
      Publisher
      Elsevier
      Collections
      • Science and Engineering Papers [3143]
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