Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      •   Research Commons
      • University of Waikato Research
      • Science and Engineering
      • Science and Engineering Papers
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      Diagnostic dilemmas associated with the pinnacle IN vaccine

      Cursons, Raymond T.; Patty, Olivia Anne; Zhang, Heng; Steward, Karen; Waller, Andrew S.
      Thumbnail
      Files
      Strangles in horses can be caused by vaccination.pdf
      1.016Mb
      Link
       www.havemeyerfoundation.org
      Citation
      Export citation
      Cursons, R. T., Patty, O., Zhang, H., Steward, K., & Waller, A. S. (2015). Diagnostic dilemmas associated with the pinnacle IN vaccine. Presented at the Havemeyer Foundation Workshop, Getting to Grips with Strangles and other Streptococcal Diseases, May 20-22, 2015, Elsinore, Denmark.
      Permanent Research Commons link: https://hdl.handle.net/10289/9938
      Abstract
      The development of clinical signs of strangles in horses following immunization with a live attenuated vaccine can present a number of diagnostic challenges. Foremost from an epidemiological perspective it is important to ascertain if the infection was due solely to the modified live vaccine, reversion of the vaccine strain to wild-type, recombination between vaccine and wild-type strains or to recent infection with a wild-type strain. To answer these diagnostics challenges we utilized next generation sequencing to confirm that two cases of strangles in previously healthy yearling horses were caused by the vaccine strain. Both isolates recovered from the two cases of vaccine-related strangles contained 67 of the 68 mutations specific for the Pinnacle vaccine. Our data shed new light on the safety of this vaccine and suggest that factors beyond the maturity of the animal’s immune system can influence the development of post-vaccination adverse reactions in some horses
      Date
      2015
      Collections
      • Science and Engineering Papers [3119]
      Show full item record  

      Usage

      Downloads, last 12 months
      28
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement