Repetitive Transcranial Magnetic Stimulation: A Call for Better Data

Simple item page
dc.contributor.authorWilson, Marcus T.en_NZ
dc.contributor.authorSt George, Lynleyen_NZ
dc.date.accessioned2017-09-19T04:13:52Z
dc.date.available2016-08-03en_NZ
dc.date.available2017-09-19T04:13:52Z
dc.date.issued2016en_NZ
dc.description.abstractRepetitive Transcranial Magnetic Stimulation (rTMS) is increasingly used to treat stroke, Parkinson's disease and depression (Fregni et al., 2005; Loo and Mitchell, 2005; Hallet, 2007; O'Reardon et al., 2007; Ridding and Rothwell, 2007). rTMS uses bursts of magnetic pulses to change the excitability and connection strengths of cortical neurons. However, the evidence to inform clinical application is highly inconsistent (Thut and Pascual-Leone, 2010; Hamada et al., 2013) and substantially based on trial and error. Systematic theory is lacking. Typically, in rTMS research, measurements of motor-evoked potential (MEP) are made, often in terms of the strength of the MEP and the length of the cortical silent period that follows. However, the MEP is probably a poor and certainly an indirect measure of changes in the brain (Nicolo et al., 2015), clouding our understanding of rTMS mechanisms. In practice, therefore, particular amplitudes and timing of pulses in an rTMS sequence are selected because they show promise in small subsets of people. However, even basics such as the sign of any change in the outcome measure (e.g., does the MEP increase or decrease?) is debated. Many results show a wide spread in responses. It has become common to talk about “responders” and “non-responders” although evidence for a binary distinction in these two groups is lacking—in reality there is usually a continuum of response often including potentiation in some and depression in others (Nettekoven et al., 2015). Moreover, Héroux et al. (2015) provide evidence that the irreproducibility of results may be due to small sample sizes, unscientific screening of subjects and data, and selective reporting of results.
dc.format.mimetypeapplication/pdf
dc.identifier.citationWilson, M. T., & St George, L. (2016). Repetitive Transcranial Magnetic Stimulation: A Call for Better Data. Frontiers in Neural Circuits, 10. https://doi.org/10.3389/fncir.2016.00057en
dc.identifier.doi10.3389/fncir.2016.00057en_NZ
dc.identifier.issn1662-5110en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/11343
dc.language.isoenen_NZ
dc.publisherFrontiers Media SAen_NZ
dc.relation.isPartOfFrontiers in Neural Circuitsen_NZ
dc.rightsCopyright © 2016 Wilson and St George. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
dc.subjectScience & Technologyen_NZ
dc.subjectLife Sciences & Biomedicineen_NZ
dc.subjectNeurosciencesen_NZ
dc.subjectNeurosciences & Neurologyen_NZ
dc.subjectrepetitive transcranial magnetic stimulation (rTMS)en_NZ
dc.subjectprincipal components analysis (PCA)en_NZ
dc.subjectmotor evoked potential (MEP)en_NZ
dc.subjectsynaptic plasticity (LTP/LTD)en_NZ
dc.subjectcorrelation analysisen_NZ
dc.subjectCORTICAL SILENT PERIODen_NZ
dc.subjectHUMAN MOTOR CORTEXen_NZ
dc.subjectFOCAL HAND DYSTONIAen_NZ
dc.subjectNEURAL FIELD-THEORYen_NZ
dc.subjectLOW-FREQUENCYen_NZ
dc.subjectCORTICOSPINAL EXCITABILITYen_NZ
dc.subjectWRITERS CRAMPen_NZ
dc.subjectINTERINDIVIDUAL VARIABILITYen_NZ
dc.subjectINTRACORTICAL INHIBITIONen_NZ
dc.subjectPARKINSONS-DISEASEen_NZ
dc.titleRepetitive Transcranial Magnetic Stimulation: A Call for Better Dataen_NZ
dc.typeJournal Article
pubs.elements-id141246
pubs.organisational-group/Waikato
pubs.organisational-group/Waikato/2018 PBRF
pubs.organisational-group/Waikato/FSEN
pubs.organisational-group/Waikato/FSEN/2018 PBRF - FSEN
pubs.organisational-group/Waikato/FSEN/School of Engineering
pubs.organisational-group/Waikato/FSEN/School of Engineering/2018 PBRF - School of Engineering
pubs.publication-statusPublisheden_NZ
pubs.user.infoWilson, Marcus (mtwilson@waikato.ac.nz)
pubs.volume10en_NZ
uow.identifier.article-noARTN 57
uow.verification.statusverified
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Repetitive Transcranial Magnetic Stimulation: A Call for Better Data.pdf
Size:
500.81 KB
Format:
Adobe Portable Document Format
Description:
Published version
Thumbnail Image
Name: Repetitive Transcranial Magnetic Stimulation: A Call for Better Data.pdf
Size: 500.81 KB
Kind: Adobe PDF
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
Research Commons Deposit Agreement 2017.pdf
Size:
188.11 KB
Format:
Adobe Portable Document Format
Description:
Name: Research Commons Deposit Agreement 2017.pdf
Size: 188.11 KB
Kind: Adobe PDF
Collections
Science and Engineering Papers