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Synthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligands

Abstract
A series of phosphine gold(I) complexes containing monoanionic thiourea ligands has been synthesised by reaction of the appropriate precursor chloro complex, Ph₃PAuCl, Cy₃PAuCl, dppf(AuCl)₂ [dppf = Fe(η⁵-C₅H₄PPh₂)₂] or dppe(AuCl)₂ (dppe = Ph₂PCH₂CH₂PPh₂) with the thiourea and Me₃N base in methanol solution. The complexes have been fully characterised by elemental analysis, NMR spectrometry, electrospray mass spectrometry, and in several cases, by single-crystal X-ray diffraction studies. The crystallographic studies show that the ligands coordinate as a thiolate in each case with systematic variations in geometric parameters being readily ascribed to the influence of the N-bound substituents. In four of the structures, discernable supramolecular aggregation patterns are evident, leading to loosely associated dimers or chain motifs, the latter mediated by either Au S, N–H N or C–H O interactions. Cytotoxicity data, against the P388 leukemia cell line, and anti-microbial data are also reported.
Type
Journal Article
Type of thesis
Series
Citation
Henderson, W., Nicholson, B. K., & Tiekink, E. R. T. (2006). Synthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligands. Inorganica Chimica Acta, 359(1), 204-214.
Date
2006-01-01
Publisher
Elsevier BV
Degree
Supervisors
Rights
The final, definitive version of this article has been published in the Journal Inorganica Chimica Acta, 359(1), (2006), (c) 2006 Elsevier, available through the ScienceDirect database.