Direct determination of vibrational density of states change on ligand binding to a protein

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dc.contributor.authorBalog, Erika
dc.contributor.authorBecker, Torsten
dc.contributor.authorOettl, Martin
dc.contributor.authorLechner, Ruep
dc.contributor.authorDaniel, Roy M.
dc.contributor.authorFinney, John L.
dc.contributor.authorSmith, Jeremy C.
dc.date.accessioned2010-04-14T00:30:14Z
dc.date.available2010-04-14T00:30:14Z
dc.date.issued2004
dc.description.abstractThe change in the vibrational density of states of a protein (dihydrofolate reductase) on binding a ligand (methotrexate) is determined using inelastic neutron scattering. The vibrations of the complex soften significantly relative to the unbound protein. The resulting free-energy change, which is directly determined by the density of states change, is found to contribute significantly to the binding equilibrium.en
dc.format.mimetypeapplication/pdf
dc.identifier.citationBalog, E., Becker, T., Oettl, M., Lechner, R., Daniel, R. M., Finney, J. & Smith, J. C. (2004). Direct determination of vibrational density of states change on ligand binding to a protein. Physical Review letters, 93(2), 028103.en
dc.identifier.doi10.1103/PhysRevLett.93.028103en
dc.identifier.urihttps://hdl.handle.net/10289/3796
dc.language.isoen
dc.publisherAmerican Physical Societyen_NZ
dc.relation.isPartOfJournal of the American Physical Societyen_NZ
dc.relation.urihttp://prl.aps.org/abstract/PRL/v93/i2/e028103en
dc.rightsThis article has been published in the journal: Physical Review letters. ©2004 The American Physical Society.en
dc.subjectproteinen
dc.subjectvibrational densityen
dc.titleDirect determination of vibrational density of states change on ligand binding to a proteinen
dc.typeJournal Articleen
pubs.begin-page1en_NZ
pubs.editionJulyen_NZ
pubs.elements-id30626
pubs.end-page4en_NZ
pubs.issue2en_NZ
pubs.volume93en_NZ
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