Metabolic adaptations associated with irreversible glucose loss are different to those observed during under-nutrition

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dc.contributor.authorMeier, S.
dc.contributor.authorGore, P.J.S.
dc.contributor.authorBarnett, Catherine Margaret Eleanor
dc.contributor.authorCursons, Raymond T.
dc.contributor.authorPhipps, D.E.
dc.contributor.authorWatkins, K.A.
dc.contributor.authorVerkerk, Gwyneth A.
dc.coverage.spatialUnited Statesen_NZ
dc.date.accessioned2010-05-03T23:51:52Z
dc.date.available2010-05-03T23:51:52Z
dc.date.issued2008
dc.description.abstractIn this study the hypothesis that irreversible glucose loss results in an ‘uncoupling’ of the somatotrophic axis (increasing plasma GH levels and decreasing plasma IGF-I) was tested. During periods of negative energy balance the somatotrophic axis respond by increasing plasma GH and decreasing plasma IGF-I levels. In turn, elevated GH repartitions nutrient by increasing lipolysis and protein synthesis, and decreases protein degradation. Irreversible glucose loss was induced using sub-cutaneous injections of phloridizin. Seven non-lactating cows were treated with 8 g/day phloridizin (PHZ) and seven control animals (CTRL, 0 g/day), while being restricted to a diet of 80% maintenance. PHZ treatment increased urinary glucose excretion (P < 0.001), resulting in hypoglycemia (P < 0.001). As a response to this glucose loss, the PHZ treated animals had elevated plasma NEFA (P < 0.005) and BHBA (P < 0.001) levels. Average plasma insulin concentrations were not altered with PHZ treatment (P = 0.059). Plasma GH was not different between the two groups (P > 0.1), whereas plasma IGF-I levels decreased significantly (P < 0.001) with PHZ treatment. The decline in plasma IGF-I concentrations was mirrored by a decrease in the abundance of hepatic IGF-I mRNA (P = 0.005), in addition the abundance of hepatic mRNA for both growth hormone receptors (GHR(tot) and GHR(1A)) was also decreased (P < 0.05). Therefore, the irreversible glucose loss resulted in a partial ‘uncoupling’ of the somatotrophic axis, as no increase in plasma GH levels occurred although plasma IGF-I levels, hepatic IGF-I mRNA declined, and the abundance of liver GH receptor mRNA declined.en
dc.identifier.citationMeier, S., Gore, P.J.S., Barnett, C.M.E., Cursons, R.T., Phipps, D.E., Watkins, K.A. & Verkerk, G.A. (2008). Metabolic adaptations associated with irreversible glucose loss are different to those observed during under-nutrition. Domestic Animal Endocrinology, 34(3), 269-277.en
dc.identifier.doi10.1016/j.domaniend.2007.08.002en
dc.identifier.urihttps://hdl.handle.net/10289/3850
dc.language.isoen
dc.publisherElsevieren_NZ
dc.relation.isPartOfDomestic Animal Endocrinologyen_NZ
dc.subjectglucoseen
dc.subjectphloridizinen
dc.subjectmetabolitesen
dc.subjectsomatotrophic axisen
dc.subjectbovineen
dc.titleMetabolic adaptations associated with irreversible glucose loss are different to those observed during under-nutritionen
dc.typeJournal Articleen
pubs.begin-page269en_NZ
pubs.elements-id33466
pubs.end-page277en_NZ
pubs.issue3en_NZ
pubs.volume34en_NZ
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