The dynamic transition in proteins may have a simple explanation

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dc.contributor.authorDaniel, Roy M.
dc.contributor.authorFinney, John L.
dc.contributor.authorSmith, Jeremy C.
dc.date.accessioned2010-08-19T01:26:20Z
dc.date.available2010-08-19T01:26:20Z
dc.date.issued2003
dc.description.abstractThe transition that has been observed in the dynamics of hydrated proteins at low temperatures (180–230 K) is normally interpreted as a change from vibrational, harmonic motion at low temperatures to anharmonic motions as the temperature is raised. It is taken to be an intrinsic property of proteins and has been associated with the onset of protein functions. Examination of the dynamic behaviour of proteins in solution within a defined timescale window suggests that certain observations can be explained without the need to invoke a discontinuity in the dynamics of proteins with temperature, i.e. the existence of a dynamical transition is not required. This is discussed in the context of recent evidence that enzyme activity is independent of the activation of anharmonic picosecond dynamics and declines steadily with temperature through the apparent dynamic transition, in accordance with the Arrhenius relationship. That similar timescale dependent dynamical behaviour has been observed experimentally in chain polymers, and seen also in computer simulations of silica glasses, suggests that the phenomenon may be of wide general relevance in both simple glassy and more complex polymeric systems.en_NZ
dc.format.mimetypeapplication/pdf
dc.identifier.citationDaniel, R.M., Finney, J.L. & Smith, J.C. (2003). The dynamic transition in proteins may have a simple explanation. Faraday Discussions, 122, 163-169.en_NZ
dc.identifier.doi10.1039/b200989gen_NZ
dc.identifier.urihttps://hdl.handle.net/10289/4369
dc.language.isoen
dc.publisherRoyal Society of Chemistryen_NZ
dc.relation.isPartOfFaraday Discussionsen_NZ
dc.relation.urihttp://www.rsc.org/Publishing/Journals/FD/article.asp?doi=b200989gen_NZ
dc.rightsThis article has been published in the journal: Faraday Discussions. ©2003 The Royal Society of Chemistry.en_NZ
dc.subjecthydrated proteinsen_NZ
dc.subjectbiologyen_NZ
dc.titleThe dynamic transition in proteins may have a simple explanationen_NZ
dc.typeJournal Articleen_NZ
pubs.begin-page163en_NZ
pubs.elements-id28348
pubs.end-page169en_NZ
pubs.volume122en_NZ
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