Synthesis, characterization and biological activity of cycloaurated organogold(III) complexes with imidate ligands

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dc.contributor.authorKilpin, Kelly Joanen_US
dc.contributor.authorHenderson, Williamen_US
dc.contributor.authorNicholson, Brian K.en_US
dc.date.accessioned2008-03-19T05:08:11Z
dc.date.available2007-10-22en_US
dc.date.available2008-03-19T05:08:11Z
dc.date.issued2007-01-01en_US
dc.description.abstractThe reactions of the cycloaurated gold(III) complexes (2-bp)AuCl2 (2-bp = 2-benzylpyridyl) or (damp)AuCl2 (damp = Me2NCH2C6H4) with an excess of sodium saccharinate (Nasacc), potassium phthalimidate (Kphth), or with isatin and trimethylamine in refluxing methanol results in the successful isolation of a series of new gold(III) imidate complexes. These were characterised by NMR and IR spectroscopies, and by X-ray structure determinations on (2-bp)Au(sacc)2 and (2-bp)Au(phth)2. In both structures, the planes of the saccharinate and the phthalimidate ligands are orientated almost perpendicular to the gold coordination plane. As expected from trans-influence considerations, the Au-N(imidate) bond lengths trans to the aryl carbon atoms are longer than the Au-N(imidate) bond lengths trans to the pyridyl groups. The complexes have also been characterised by electrospray ionisation MS; in the presence of halide ligands, one imidate ligand is readily displaced. Anti-tumour (P388 murine leukemia) and selected anti-microbial data for the new complexes are reported. Surprisingly, all three damp complexes had low anti-tumour activity, which is likely to be a consequence of the poor solubility of these complexes. The synthesis and characterisation of a related gold(III) bis(amidate) complex derived from sulfathiazole is also described.en_US
dc.identifier.citationKilpin, K.J., Henderson, W. & Nicholson, B.K. (2007). Synthesis, characterization and biological activity of cycloaurated organogold(III) complexes with imidate ligands. Polyhedron, 26(1), 204-213.en_US
dc.identifier.doi10.1016/j.poly.2006.08.009en_US
dc.identifier.urihttps://hdl.handle.net/10289/191
dc.language.isoen
dc.publisherPergamonen_NZ
dc.relation.isPartOfPolyhedronen_NZ
dc.rightsThis article is published in the journal, Polyhedron, (c) 2006 Elsevier Ltd.en_US
dc.subjectGold complexesen_US
dc.subjectImidate ligandsen_US
dc.subjectCrystal structuresen_US
dc.subjectElectrospray mass spectrometryen_US
dc.subjectBiological activityen_US
dc.titleSynthesis, characterization and biological activity of cycloaurated organogold(III) complexes with imidate ligandsen_US
dc.typeJournal Articleen_US
pubs.begin-page204en_NZ
pubs.elements-id32652
pubs.end-page213en_NZ
pubs.issue1en_NZ
pubs.volume26en_NZ
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