Enzyme evolution: innovation is easy, optimization is complicated

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dc.contributor.authorNewton, Matilda S.en_NZ
dc.contributor.authorArcus, Vickery L.en_NZ
dc.contributor.authorGerth, Monica L.en_NZ
dc.contributor.authorPatrick, Wayne M.en_NZ
dc.date.accessioned2018-03-27T01:30:43Z
dc.date.available2018en_NZ
dc.date.available2018-03-27T01:30:43Z
dc.date.issued2018en_NZ
dc.description.abstractEnzymes have been evolving to catalyze new chemical reactions for billions of years, and will continue to do so for billions more. Here, we review examples in which evolutionary biochemists have used big data and high-throughput experimental tools to shed new light on the enormous functional diversity of extant enzymes, and the evolutionary processes that gave rise to it. We discuss the role that gene loss has played in enzyme evolution, as well as the more familiar processes of gene duplication and divergence. We also review insightful studies that relate not only catalytic activity, but also a host of other biophysical and cellular parameters, to organismal fitness. Finally, we provide an updated perspective on protein engineering, based on our new-found appreciation that most enzymes are sloppy and mediocre.en_NZ
dc.format.mimetypeapplication/pdf
dc.identifier.citationNewton, M. S., Arcus, V. L., Gerth, M. L., & Patrick, W. M. (2018). Enzyme evolution: innovation is easy, optimization is complicated. Current Opinion in Structural Biology, 48, 110–116. https://doi.org/10.1016/j.sbi.2017.11.007en
dc.identifier.doi10.1016/j.sbi.2017.11.007en_NZ
dc.identifier.eissn1879-033Xen_NZ
dc.identifier.issn0959-440Xen_NZ
dc.identifier.urihttps://hdl.handle.net/10289/11750
dc.language.isoen
dc.publisherElsevieren_NZ
dc.relation.isPartOfCurrent Opinion in Structural Biologyen_NZ
dc.rights© 2017 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.titleEnzyme evolution: innovation is easy, optimization is complicateden_NZ
dc.typeJournal Article
pubs.begin-page110
pubs.elements-id215678
pubs.end-page116
pubs.organisational-group/Waikato
pubs.organisational-group/Waikato/2018 PBRF
pubs.organisational-group/Waikato/FSEN
pubs.organisational-group/Waikato/FSEN/2018 PBRF - FSEN
pubs.organisational-group/Waikato/FSEN/School of Science
pubs.organisational-group/Waikato/FSEN/School of Science/2018 PBRF - School of Science
pubs.user.infoArcus, Vickery (varcus@waikato.ac.nz)
pubs.volume48en_NZ
uow.verification.statusverified
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