Organogold(III) complexes containing chelating bis(amidate) ligands: synthesis, characterization and biological activity

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dc.contributor.authorKilpin, Kelly Joanen_US
dc.contributor.authorHenderson, Williamen_US
dc.contributor.authorNicholson, Brian K.en_US
dc.date.accessioned2008-03-19T05:08:11Z
dc.date.available2007-10-22en_US
dc.date.available2008-03-19T05:08:11Z
dc.date.issued2007-01-01en_US
dc.description.abstractReactions of cycloaurated gold(III) dichloride complexes, with 1,2-C6H4(NHCOMe)2 and silver(I) oxide, or with C2H4(NHSO2Tol)2 (Tol = p-tolyl) or 1,2-C6H4(NHSO2Tol)2 and trimethylamine, give a series of new auracyclic complexes containing the Au-NR-CH2CH2-NR (R = SO2Tol) and Au-NR-C6H4-NR (R = COMe or SO2Tol) five-membered ring systems. An X-ray structure determination on (2-bp)Au{N(COMe)C6H4N(COMe)} (2-bp = cycloaurated 2-benzylpyridine) shows the presence of puckered metallacyclic rings, with both acetyl substituents positioned below the Au(III) coordination plane. The complex (2-bp)Au{N(COMe)C6H4N(COMe)} undergoes ring cleavage in the presence of halide and water, to give the complex (2-bp)Au{N(COMe)C6H4NH(COMe)}Cl, which was characterised crystallographically, and shown to contain a monodentate amidate ligand. Biological activity studies of the new auracyclic complexes are also reported, against P388 murine leukaemia cells and a range of bacteria and fungi, with a number of complexes showing high activity.en_US
dc.identifier.citationKilpin, K.J., Henderson, W. & Nicholson, B.K. (2007). Organogold(III) complexes containing chelating bis(amidate) ligands: synthesis, characterization and biological activity. Polyhedron, 26(2), 434-447.en_US
dc.identifier.doi10.1016/j.poly.2006.06.036en_US
dc.identifier.urihttps://hdl.handle.net/10289/130
dc.language.isoen
dc.publisherElsevier BVen_NZ
dc.relation.isPartOfPolyhedronen_NZ
dc.rightsThis article is published in the journal, Polyhedron, (c) 2006 Elsevier Ltd.en_US
dc.subjectGold complexesen_US
dc.subjectMetallacylic complexesen_US
dc.subjectCrystal structuresen_US
dc.subjectElectrospray mass spectrometryen_US
dc.subjectAnti-tumour activityen_US
dc.titleOrganogold(III) complexes containing chelating bis(amidate) ligands: synthesis, characterization and biological activityen_US
dc.typeJournal Articleen_US
pubs.begin-page434en_NZ
pubs.elements-id32240
pubs.end-page447en_NZ
pubs.issue2en_NZ
pubs.volume26en_NZ
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