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dc.contributor.advisorRathbone, Michael J.
dc.contributor.advisorEllis, Keith
dc.contributor.advisorSwan, Janis E.
dc.contributor.authorSyzov, Vladyslaven_NZ
dc.date.accessioned2008-04-03T09:05:50Z
dc.date.available2008-08-01T12:00:12Z
dc.date.issued2008en_NZ
dc.identifier.citationSyzov, V. (2008). Delivery of a coated bioactive from a rumen controlled-release device (Thesis, Master of Engineering (ME)). The University of Waikato, Hamilton, New Zealand. Retrieved from https://hdl.handle.net/10289/2368en
dc.identifier.urihttps://hdl.handle.net/10289/2368
dc.description.abstractRuminants possess a unique digestive system. Using the high metabolic potential of the symbiotic microflora of the rumen, ruminants are capable of digesting plant material and obtaining nutrients and energy from this process. Because of the ruminal fermentation, the most bioactives are not stable in the harsh ruminal environment. Therefore there is a need to improve the bioavailability of a bioactive by protecting it from the ruminal digestion. The formulation of protected bioactive can be delivered in the rumen in a controlled manner and over a long period of time. In this project the degree of rumen protection was estimated using model substrates (sugar pellets and granules). These materials were coated with the pH-sensitive polymer Eudragit E. The model bioactive (phloridizin) was coated using the coating methodology adopted from exploratory studies with model substrates. The bioavailability of protected (coated) phloridizin was assessed by administering directly into the abomasum of fistulated cows. Formulation of protected phloridizin was used to demonstrate the feasibility of bioactive controlled delivery based on ART ( Active Rumen Technology ). This technology uses an elevated gas pressure created by a hydrogen-producing cell to drive a plunger which extrudes bioactive formulation from an intraruminal controlled-release device. Four groups of devices filled with formulation containing different amounts of protected phloridizin were tested. The bioactive was released in a controlled manner over several days. The formulation release profiles were reproducible suggesting that in principle the technology can be further developed to use in a commercial sense or for research purposes. The limitations of the technology, including formulation issues and gas diffusion through barrel walls, were identified.en_NZ
dc.format.mimetypeapplication/pdf
dc.language.isoen
dc.publisherThe University of Waikatoen_NZ
dc.rightsAll items in Research Commons are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subjectEudragit E100en_NZ
dc.subjectpan coatingen_NZ
dc.subjectphloridizinen_NZ
dc.subjectrumen deviceen_NZ
dc.titleDelivery of a coated bioactive from a rumen controlled-release deviceen_NZ
dc.typeThesisen_NZ
thesis.degree.disciplineScience and Engineeringen_NZ
thesis.degree.grantorUniversity of Waikatoen_NZ
thesis.degree.levelMasters
thesis.degree.nameMaster of Engineering (ME)en_NZ
uow.date.accession2008-04-03T09:05:50Zen_NZ
uow.date.available2008-08-01T12:00:12Zen_NZ
uow.identifier.adthttp://adt.waikato.ac.nz/public/adt-uow20080403.090550en_NZ
uow.date.migrated2009-06-09T23:31:39Zen_NZ
pubs.place-of-publicationHamilton, New Zealanden_NZ


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