Research Commons
      • Browse 
        • Communities & Collections
        • Titles
        • Authors
        • By Issue Date
        • Subjects
        • Types
        • Series
      • Help 
        • About
        • Collection Policy
        • OA Mandate Guidelines
        • Guidelines FAQ
        • Contact Us
      • My Account 
        • Sign In
        • Register
      View Item 
      •   Research Commons
      • University of Waikato Theses
      • Masters Degree Theses
      • View Item
      •   Research Commons
      • University of Waikato Theses
      • Masters Degree Theses
      • View Item
      JavaScript is disabled for your browser. Some features of this site may not work without it.

      The Composition of Arylstibonic Acids

      Wright, Cody Elvin
      Thumbnail
      Files
      thesis.pdf
      4.439Mb
      Citation
      Export citation
      Wright, C. E. (2010). The Composition of Arylstibonic Acids (Thesis, Master of Science (MSc)). University of Waikato, Hamilton, New Zealand. Retrieved from https://hdl.handle.net/10289/5146
      Permanent Research Commons link: https://hdl.handle.net/10289/5146
      Abstract
      This thesis describes a detailed ESI-MS investigation into the arylstibonic acids, organo-antimony-containing compounds that are currently of interest as anticancer reagents. Four arylstibonic acids, of nominal formula RC6H4SbO3H2 [R = p-chloro-, p-tolyl-, p-nitro- and α-naphthyl-] were synthesised, and a further eight archival samples from the National Cancer Institute Repository were obtained for use in the project. Results indicate clearly that the acids exist as polyoxometalate aggregates [H8(RSb)12O28], rather than monomeric species, in both the solid state and in acetonitrile solution, thus resolving a century-old debate concerning the nature of their molecular composition. Variations in solvent, time in solution and pH have also defined the stability of these aggregates under different conditions. Synthesis of arylstibonic acids by traditional methods (pre-1940) has been shown to lead to products contaminated with cations present during their preparation. An improved method of synthesis has been devised, and the crystal structure of an intermediate in the synthesis of these acids, [C6NH6][p-O2NC6H4SbCl5], is reported. Salts of arylstibonic acids with a range of cations were investigated by ESI-MS and shown to form a diverse family of polyoxostibonates with nuclearities including Sb12, Sb14 and Sb16. Crystal structures containing some of these aggregates, verified through parallel studies with collaborators, are described. Preliminary study of mixed polyoxometalates (Sb/As) showed a strong tendency to form As4Sb2 species but these could not be fully characterised.
      Date
      2010
      Type
      Thesis
      Degree Name
      Master of Science (MSc)
      Supervisors
      Nicholson, Brian K.
      Publisher
      University of Waikato
      Rights
      All items in Research Commons are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
      Collections
      • Masters Degree Theses [2381]
      Show full item record  

      Usage

      Downloads, last 12 months
      41
       
       

      Usage Statistics

      For this itemFor all of Research Commons

      The University of Waikato - Te Whare Wānanga o WaikatoFeedback and RequestsCopyright and Legal Statement