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      Treatment for depression following mild traumatic brain injury in adults: A meta-analysis

      Barker-Collo, Suzanne; Starkey, Nicola J.; Theadom, Alice
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      Syst review mTBI depression _accepted version.pdf
      Accepted version, 753.6Kb
      DOI
       10.3109/02699052.2013.801513
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      Barker-Collo, S., Starkey, N. J., & Theadom, A. (2013). Treatment for depression following mild traumatic brain injury in adults: A meta-analysis. Brain Injury, 27(10), 1124–1133. http://doi.org/10.3109/02699052.2013.801513
      Permanent Research Commons link: https://hdl.handle.net/10289/8957
      Abstract
      Primary objective: Development of depression after TBI is linked to poorer outcomes. The aim of this manuscript is to review evidence for the effectiveness of current treatments.

      Research design: Two meta-analyses were undertaken to examine the effectiveness of both pharmacological and non-pharmacological interventions for depression after mild TBI

      Method and procedures: PubMed, Medline, PsychInfo, Web of Science and Digital Dissertations were searched and 13 studies located. Meta Analyst Beta 3.13 was used to conduct analyses of pre- vs post-effects then to examine treatment group vs control group effects.

      Main outcomes and results: Studies using a pre–post design produced an overall effect size of 1.89 (95% CI = 1.20–2.58, p < 0.001), suggesting that treatments were effective; however, the overall effect for controlled trials was 0.46 (95% CI = −0.44–1.36, p < 0.001), which favoured the control rather than treatment groups.

      Conclusions: This study highlights the need for additional large well-controlled trials of effective treatments for depression post-TBI.
      Date
      2013
      Type
      Journal Article
      Publisher
      INFORMA HEALTHCARE
      Rights
      This is an author’s accepted version of an article published in the journal: Brain Injury. © 2013 Informa UK Ltd.
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      • Arts and Social Sciences Papers [1423]
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