Synthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligands

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dc.contributor.authorHenderson, Williamen_US
dc.contributor.authorNicholson, Brian K.en_US
dc.contributor.authorTiekink, Edward R. T.en_US
dc.date.accessioned2008-03-19T05:11:00Z
dc.date.available2007-08-12en_US
dc.date.available2008-03-19T05:11:00Z
dc.date.issued2006-01-01en_US
dc.description.abstractA series of phosphine gold(I) complexes containing monoanionic thiourea ligands has been synthesised by reaction of the appropriate precursor chloro complex, Ph₃PAuCl, Cy₃PAuCl, dppf(AuCl)₂ [dppf = Fe(η⁵-C₅H₄PPh₂)₂] or dppe(AuCl)₂ (dppe = Ph₂PCH₂CH₂PPh₂) with the thiourea and Me₃N base in methanol solution. The complexes have been fully characterised by elemental analysis, NMR spectrometry, electrospray mass spectrometry, and in several cases, by single-crystal X-ray diffraction studies. The crystallographic studies show that the ligands coordinate as a thiolate in each case with systematic variations in geometric parameters being readily ascribed to the influence of the N-bound substituents. In four of the structures, discernable supramolecular aggregation patterns are evident, leading to loosely associated dimers or chain motifs, the latter mediated by either Au S, N–H N or C–H O interactions. Cytotoxicity data, against the P388 leukemia cell line, and anti-microbial data are also reported.en_US
dc.identifier.citationHenderson, W., Nicholson, B. K., & Tiekink, E. R. T. (2006). Synthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligands. Inorganica Chimica Acta, 359(1), 204-214.en_US
dc.identifier.doi10.1016/j.ica.2005.07.046
dc.identifier.urihttps://hdl.handle.net/10289/202
dc.language.isoen
dc.publisherElsevier BVen_NZ
dc.relation.isPartOfInorganica Chimica Actaen_NZ
dc.rightsThe final, definitive version of this article has been published in the Journal Inorganica Chimica Acta, 359(1), (2006), (c) 2006 Elsevier, available through the ScienceDirect database.en_US
dc.subjectgolden_US
dc.subjectphosphine complexesen_US
dc.subjectthiourea complexesen_US
dc.subjectcytotoxicityen_US
dc.subjectanti-microbial activityen_US
dc.subjectsupramolecular aggregationen_US
dc.titleSynthesis, characterisation, supramolecular aggregation and biological activity of phosphine gold(I) complexes with monoanionic thiourea ligandsen_US
dc.typeJournal Articleen_US
pubs.begin-page204en_NZ
pubs.elements-id31623
pubs.end-page214en_NZ
pubs.issue1en_NZ
pubs.volume359en_NZ
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