Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis

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dc.contributor.authorEllis, Haylee Mareeen_NZ
dc.contributor.authorMulder, Christiaanen_NZ
dc.contributor.authorValverde, Emilioen_NZ
dc.contributor.authorPoling, Alanen_NZ
dc.contributor.authorEdwards, Timothy L.en_NZ
dc.date.accessioned2017-05-05T02:41:51Z
dc.date.available2017en_NZ
dc.date.available2017-05-05T02:41:51Z
dc.date.issued2017en_NZ
dc.description.abstractBackground: African pouched rats sniffing sputum samples provided by local clinics have significantly increased tuberculosis case findings in Tanzania and Mozambique. The objective of this study was to determine the reproducibility of rat results. Methods: Over an 18-month period 11,869 samples were examined by the rats. Intra-rater reliability was assessed through Yule’s Q. Inter-rater reliability was assessed with Krippendorff’s alpha. Results: Intra-rater reliability was high, with a mean Yule’s Q of 0.9. Inter-rater agreement was fair, with Krippendorf’s alpha ranging from 0.15 to 0.45. Both Intra- and Inter-rater reliability was independent of the sex of the animals, but they were positively correlated with age. Both intra- and inter-rater agreement was lowest for samples designated as smear-negative by the clinics. Conclusion: Overall, the reproducibility of tuberculosis detection rat results was fair and diagnostic results were therefore independent of the rats used.
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dc.identifier.citationEllis, H. M., Mulder, C., Valverde, E., Poling, A., & Edwards, T. L. (2017). Reproducibility of African giant pouched rats detecting Mycobacterium tuberculosis. BMC Infectious Diseases, 17(1). https://doi.org/10.1186/s12879-017-2347-3en
dc.identifier.doi10.1186/s12879-017-2347-3en_NZ
dc.identifier.eissn1471-2334en_NZ
dc.identifier.urihttps://hdl.handle.net/10289/11030
dc.language.isoen
dc.relation.isPartOfBMC Infectious Diseasesen_NZ
dc.rights© The Author(s). 2017 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
dc.subjectTuberculosis
dc.subjectDiagnosis
dc.subjectReproducibility
dc.subjectDetection rats
dc.subjectInter-rater reliability
dc.subjectIntra-rater reliability
dc.titleReproducibility of African giant pouched rats detecting Mycobacterium tuberculosisen_NZ
dc.typeJournal Article
pubs.elements-id193961
pubs.issue1en_NZ
pubs.organisational-group/Waikato
pubs.organisational-group/Waikato/2018 PBRF
pubs.organisational-group/Waikato/FASS
pubs.organisational-group/Waikato/FASS/2018 PBRF - FASS
pubs.organisational-group/Waikato/FASS/School of Psychology
pubs.publication-statusPublished onlineen_NZ
pubs.volume17en_NZ
uow.verification.statusunverified
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