Novel Brominated Alkaloids from the Bryozoan Amathia citrina

Shrubsall, Jacob

Novel Brominated Alkaloids from the Bryozoan Amathia citrina

dc.contributor.advisor	Prinsep, Michèle R.
dc.contributor.author	Shrubsall, Jacob
dc.date.accessioned	2017-07-13T04:22:35Z
dc.date.available	2017-07-13T04:22:35Z
dc.date.issued	2017
dc.date.updated	2017-04-27T23:56:57Z
dc.description.abstract	Sixteen bryozoan species from the United Kingdom and New Zealand were surveyed for the presence of brominated secondary metabolites by Liquid Chromatography tandem Mass Spectrometry (LCMS) analysis. Brominated metabolites were detected in six of these samples. Collections of the species Amathia citrina and Amathia verticillata were determined as ideal candidates for a natural products study due to the presence of potentially novel brominated secondary metabolites in reasonable abundance. The sample with the greatest number and seemingly highest concentration of brominated secondary metabolites, of all species surveyed, was the species Amathia citrina (previously Bowerbankia citrina) from Swansea, Wales, and so was selected as the candidate for this study. Eight related metabolites were detected in A. citrina, speculated to be a family of brominated alkaloids. Attempts were made to isolate and purify two members of this family of compounds by reversed-phase and size exclusion chromatography, but were unable to be obtained in a pure state. Nevertheless, they were then partially characterised by mass spectrometry (MS) and nuclear magnetic resonance (NMR) spectroscopy to be discovered as a new family of brominated indole alkaloids, tentatively named the amathamines.
dc.format.mimetype	application/pdf
dc.identifier.citation	Shrubsall, J. (2017). Novel Brominated Alkaloids from the Bryozoan Amathia citrina (Thesis, Master of Science (MSc)). University of Waikato, Hamilton, New Zealand. Retrieved from https://hdl.handle.net/10289/11176	en
dc.identifier.uri	https://hdl.handle.net/10289/11176
dc.language.iso	en
dc.publisher	University of Waikato
dc.rights	All items in Research Commons are provided for private study and research purposes and are protected by copyright with all rights reserved unless otherwise indicated.
dc.subject	Natural Products
dc.subject	Bryozoa
dc.subject	Amathia citrina
dc.title	Novel Brominated Alkaloids from the Bryozoan Amathia citrina
dc.type	Thesis
pubs.place-of-publication	Hamilton, New Zealand	en_NZ
thesis.degree.grantor	University of Waikato
thesis.degree.level	Masters
thesis.degree.name	Master of Science (MSc)